Isaac ben Joseph Caro (d. 1518–1535) was a rabbi and scholar of the generation of the expulsion from Spain. Born in Toledo, Caro had a superb religious education and also studied medicine. He was called to become the head of the yeshiva in Lisbon, whence he was exiled in 1497. He then settled in Istanbul, where he established himself as a respected halakhic scholar. It is known that for a while he also lived in the city of Manisa in western Anatolia. If Caro had children, none of them survived childhood, but he raised and educated his nephew Joseph ben Ephraim Caro (1488–1575), the author of th…