The Meyuḥas family left Spain in 1492 during the expulsion and arrived in Jerusalem in 1510. Their earliest affiliation was with the Yoḥanan ben Zakkay Synagogue in the Old City. Other members of the family settled in Greece, Turkey, and elsewhere in the Ottoman Empire.

The brothers Abraham ben Samuel Meyuḥas (d. 1767) and Raphael ben Samuel Meyuḥas (1695–1771) both studied in the Bet Yaʿaqov Yeshiva. Raphael subsequently became its head. Abraham was a noted kabbalist whose commentaries and conclusions were incorporated into the final recensions of the Lurianic canon (see Mysticism). …